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PGT-A

PGT-A

What is PGT-A?

At Hzb Aarogyam Fertility Care and Endancy Centre, we offer Preimplantation Genetic Testing for Aneuploidy (PGT-A), a cutting-edge technology that helps identify chromosomal abnormalities in embryos created through In Vitro Fertilization (IVF).​

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PGT-A is a valuable tool for individuals and couples who

- ​Have experienced recurrent miscarriages or failed IVF cycles

- Are at risk of passing on genetic disorders to their offspring

- Are concerned about the risk of chromosomal abnormalities, such as Down syndrome

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By analyzing embryos for genetic anomalies, PGT-A enables our fertility specialists to

- Select healthy embryos for transfer, increasing the chances of a successful pregnancy

- Reduce the risk of miscarriage, failed implantation, and birth defects

- Provide emotional reassurance and minimize the risk of genetic disorders

​

Our PGT-A program is designed to support individuals and couples in achieving their reproductive goals, while minimizing the risk of genetic abnormalities.

Overview

At Hzb Arogyam Fertility Care and Endoscopy Centre, we offer Preimplantation Genetic Testing for Aneuploidy (PGT-A) to support individuals and couples undergoing In Vitro Fertilization (IVF). PGT-A is a valuable tool for identifying chromosomal abnormalities in embryos, which can lead to miscarriage, failed implantation, or birth defects.


PGT-A involves analyzing the 23 pairs of human chromosomes in embryos at the blastocyst stage. This test helps determine why some individuals experience recurrent pregnancy losses or unsuccessful fertility cycles. By selecting the healthiest embryos for transfer, PGT-A can increase the overall success rate of IVF.

Who Can Benefit from PGT-A?

PGT-A is particularly recommended for:​

  • Individuals undergoing IVF after multiple infertility treatments

  • Those prone to spontaneous miscarriages

  • Families with a history of genetic disorders

  • Women over 35 years old undergoing IVF

  • Couples who have had previous pregnancies with chromosomal anomalies

Benefits of PGT-A

PGT-A offers several benefits, including:​

  • Increased IVF success rates

  • Reduced risk of spontaneous abortion

  • Minimized risk of implanting an embryo with chromosomal anomalies

  • Identification of potential genetic disorders

  • Selection of the best embryo, reducing the need for multiple embryo transfers

PGT-A  Procedure

  • Stage 1: Birth Control Pills or Oestrogen
    Your doctor may recommend oestrogen or birth control tablets before you begin IVF therapy. This is used to regulate the time of your menstrual cycle and prevent the growth of ovarian cysts. It enables your doctor to manage your treatment and increase the number of mature eggs collected during the egg retrieval operation.
  • Stage 2: Ovarian Stimulation
    In a normal woman, each menstrual cycle results in the production of one egg. However, several eggs are necessary for IVF. The likelihood of creating a healthy embryo improves when more than one egg is used. To boost your body's egg production, you'll be given fertility medications. You'll be prescribed injectable hormone medications during your IVF cycle to encourage all of the eggs in that cycle to develop at once and completely.
  • Stage 3: Ultrasound Examination
    To evaluate how well the medications on your ovaries are working, a vaginal ultrasound test is performed at regular intervals. If the outcome is bad, it's possible that your doctor will suggest stopping the IVF treatment cycle. You and your doctor will decide together on this.
  • Stage 4: Egg Retrieval
    The egg retrieval procedure is carried out 36 hours following your hormone IVF injections given for stimulation. Transvaginal sonography is used to help retrieve eggs from the ovaries while the patient is under general anesthesia. Your reaction to the medications will determine how many eggs are collected, and the operation lasts 15 to 30 minutes. Around two to three hours following the treatment, you can leave for home. Sometimes there may be some stomach pain and vaginal spotting, but these symptoms usually go away in a day or two.
  • Stage 5: Sperm Collection
    A sample of semen is required from your spouse. On the day the eggs are harvested, a sample of fresh semen is often taken. A previously frozen sample can also be used, though, if a fresh sample can't be made on the same day or if the spouse isn't there on the day, the eggs are collected. The sperm and the eggs will be combined by a technician in a petri dish. If it fails to result in embryos, your doctor can choose to perform ICSI.
  • Stage 6: Fertilizing the Eggs
    The eggs will be fertilized in the laboratory, either through ICSI or traditional IVF. The embryologist will check the eggs the following day to see whether they have been fertilized and then later to see if any embryos have developed further. It is possible to freeze additional well-developed embryos if there are more than three for eventual later transfer.
  • Stage 7: Embryo Culture
    The fertilized eggs (embryos) are nurtured in a controlled environment, allowing them to grow and develop.
  • Stage 8: Embryo Transfer
    This is done two, three, or five days following egg harvest. To decide if a day 3 or day 5 transfer is necessary, embryologists keep an eye on the development and viability of the embryos. The embryo is positioned in your uterus using a tiny catheter that is implanted. It takes between six and ten days for the implantation to take place if the operation is successful. A course of medicines to assist the luteal phase will be provided to you after the transfer.
  • Stage 9: Pregnancy Test
    A pregnancy blood test is carried out after two weeks following extraction. In the event that the test is positive, the patient is thought to be four weeks pregnant.

At Hzb Arogyam Fertility Care and Endoscopy Centre, our experienced fertility specialists guide you through the PGT-A procedure, which involves the following steps:

A laboratory technician in a white lab coat using a microscope to study a sample closely.

Types of PGT-A Tests

PGS (Preimplantation Genetic Screening):

Screens embryos for chromosomal abnormalities, ensuring 23 perfect pairs of chromosomes.​

​

PGD (Preimplantation Genetic Diagnosis):

Examines embryos for specific genetic conditions or single gene defects identified in one or both parents.

Risks and Considerations

While PGT-A is a valuable tool, it's essential to consider the potential risks and limitations, including:

  • Risks related to ovarian hyperstimulation syndrome, multiple pregnancies, and birth abnormalities

  • Pelvic infection, miscarriage, and ectopic pregnancy risks

  • Embryo biopsy and freezing risks

  • No guarantee of a healthy child, as testing may not detect every genetic illness or abnormality

PGT-A Cost

At Hzb Arogyam Fertility Care and Endoscopy Centre, we understand that the cost of PGT-A can vary significantly from patient to patient. Several factors influence the cost of PGT-A testing, including:

  • Number of embryos to be tested

  • Genetic disease inheritance pattern

  • Equipment required for PGT-A testing

  • Frequency of IVF cycles needed

  • Age of the individual

  • Number of embryos available

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The cost of PGT-A testing is typically determined per embryo by genetic laboratories. As the number of embryos to be tested increases, so does the expense.


It's essential to note that the cost of PGT-A may not be covered by insurance, making it a significant out-of-pocket expense. However, in some cases, health insurance policies may cover associated costs when genetic testing is prescribed by a fertility doctor.


To get a personalized estimate of the PGT-A cost, we recommend scheduling a consultation with our fertility specialists. They will assess your individual case and provide a detailed breakdown of the costs involved.

Why Choose Arogyam IVF?

At Arogyam IVF, we offer a comprehensive range of fertility treatments, backed by a strong network, experienced doctors,

and a patient-centric approach. Here's what sets Arogyam IVF apart:​​​​

​

  1. Exceptional Success Rates: Arogyam IVF has achieved remarkable success rates, thanks to our cutting-edge technology, expert doctors, and personalized care.

  2. State-of-the-Art Infrastructure: Our modern fertility clinic is equipped with the latest technology, ensuring efficient and effective treatment.

  3. Experienced Fertility Specialists: Our team of experienced fertility doctors works closely with each patient, providing expert guidance and tailored treatment plans.

  4. Personalized Fertility Treatment: We recognize that each couple's fertility journey is unique. Our personalized approach focuses on individual medical history, diagnosis, and specific needs.

  5. Comprehensive Fertility Services: Arogyam IVF offers a wide range of fertility treatments, including IVF, ICSI, IUI, Cryopreservation, and Donor Programs.

  6. Patient-Centric Care: Our dedicated team provides compassionate support and guidance throughout your fertility journey, ensuring a seamless and stress-free experience.​

Frequently Asked Question's

At Hzb Arogyam Fertility Care and Endoscopy Centre, we understand that you may have questions about Preimplantation Genetic Testing (PGT). Here are some frequently asked questions and their answers:

  • Stage 1: Birth Control Pills or Oestrogen
    Your doctor may recommend oestrogen or birth control tablets before you begin IVF therapy. This is used to regulate the time of your menstrual cycle and prevent the growth of ovarian cysts. It enables your doctor to manage your treatment and increase the number of mature eggs collected during the egg retrieval operation.
  • Stage 2: Ovarian Stimulation
    In a normal woman, each menstrual cycle results in the production of one egg. However, several eggs are necessary for IVF. The likelihood of creating a healthy embryo improves when more than one egg is used. To boost your body's egg production, you'll be given fertility medications. You'll be prescribed injectable hormone medications during your IVF cycle to encourage all of the eggs in that cycle to develop at once and completely.
  • Stage 3: Ultrasound Examination
    To evaluate how well the medications on your ovaries are working, a vaginal ultrasound test is performed at regular intervals. If the outcome is bad, it's possible that your doctor will suggest stopping the IVF treatment cycle. You and your doctor will decide together on this.
  • Stage 4: Egg Retrieval
    The egg retrieval procedure is carried out 36 hours following your hormone IVF injections given for stimulation. Transvaginal sonography is used to help retrieve eggs from the ovaries while the patient is under general anesthesia. Your reaction to the medications will determine how many eggs are collected, and the operation lasts 15 to 30 minutes. Around two to three hours following the treatment, you can leave for home. Sometimes there may be some stomach pain and vaginal spotting, but these symptoms usually go away in a day or two.
  • Stage 5: Sperm Collection
    A sample of semen is required from your spouse. On the day the eggs are harvested, a sample of fresh semen is often taken. A previously frozen sample can also be used, though, if a fresh sample can't be made on the same day or if the spouse isn't there on the day, the eggs are collected. The sperm and the eggs will be combined by a technician in a petri dish. If it fails to result in embryos, your doctor can choose to perform ICSI.
  • Stage 6: Fertilizing the Eggs
    The eggs will be fertilized in the laboratory, either through ICSI or traditional IVF. The embryologist will check the eggs the following day to see whether they have been fertilized and then later to see if any embryos have developed further. It is possible to freeze additional well-developed embryos if there are more than three for eventual later transfer.
  • Stage 7: Embryo Culture
    The fertilized eggs (embryos) are nurtured in a controlled environment, allowing them to grow and develop.
  • Stage 8: Embryo Transfer
    This is done two, three, or five days following egg harvest. To decide if a day 3 or day 5 transfer is necessary, embryologists keep an eye on the development and viability of the embryos. The embryo is positioned in your uterus using a tiny catheter that is implanted. It takes between six and ten days for the implantation to take place if the operation is successful. A course of medicines to assist the luteal phase will be provided to you after the transfer.
  • Stage 9: Pregnancy Test
    A pregnancy blood test is carried out after two weeks following extraction. In the event that the test is positive, the patient is thought to be four weeks pregnant.

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