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DFI

DFI

What is DFI?

At Hzb Arogyam Fertility Care and Endoscopy Centre, we understand the importance of assessing sperm health to optimize fertility outcomes. The Sperm DNA Fragmentation Index (DFI) is a vital diagnostic tool that measures the extent of damage to the DNA within sperm cells.


DFI testing helps our fertility experts evaluate the integrity of sperm DNA, identifying potential damage that may impact fertility. By assessing DFI, we can better understand the underlying causes of infertility and develop personalized treatment plans to enhance fertility potential.

Overview

At Hzb Arogyam Fertility Care and Endoscopy Centre, we recognize that male factor infertility plays a significant role in many cases of infertility, with approximately 50% of conditions linked to male-related issues.​

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Traditional semen analysis, which assesses sperm concentration, motility, and morphology, has long been the standard evaluation for male fertility. However, this analysis does not provide insight into the genetic integrity of the sperm, a crucial factor for healthy embryo development.

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Sperm DNA Fragmentation (DFI) testing offers a more comprehensive understanding of sperm health, enabling our fertility experts to identify potential issues that may impact fertility outcomes. High DFI has been linked to various factors, including advanced age, inflammation, unhealthy lifestyle habits, and environmental exposures.

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By incorporating DFI testing into our diagnostic toolkit, we can better evaluate male fertility potential, address underlying causes of infertility, and develop personalized treatment plans to optimize outcomes for our patients.

Why is it Done?

At Hzb Arogyam Fertility Care and Endoscopy Centre, we recommend Sperm DNA Fragmentation (DFI) testing to diagnose and address underlying male infertility issues, particularly in cases of:

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  • Unexplained infertility

  • History of poor or arrested embryonic development

  • Multiple failed Assisted Reproductive Technology (ART) cycles

  • Recurrent miscarriage

  • Advanced male age

  • Varicocele

  • Abnormal semen analysis

  • Exposure to harmful substances, tobacco, alcohol, radiation, and other environmental factors

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By conducting DFI testing, our fertility experts can identify potential sperm DNA damage, which may be contributing to infertility or recurrent pregnancy loss. This critical information enables us to develop personalized treatment plans and improve fertility outcomes for our patients.

DFI Procedure

This comprehensive evaluation provides us with critical insights into sperm health, enabling our fertility specialists to develop personalized treatment plans tailored to your unique needs.

  • Stage 1: Birth Control Pills or Oestrogen
    Your doctor may recommend oestrogen or birth control tablets before you begin IVF therapy. This is used to regulate the time of your menstrual cycle and prevent the growth of ovarian cysts. It enables your doctor to manage your treatment and increase the number of mature eggs collected during the egg retrieval operation.
  • Stage 2: Ovarian Stimulation
    In a normal woman, each menstrual cycle results in the production of one egg. However, several eggs are necessary for IVF. The likelihood of creating a healthy embryo improves when more than one egg is used. To boost your body's egg production, you'll be given fertility medications. You'll be prescribed injectable hormone medications during your IVF cycle to encourage all of the eggs in that cycle to develop at once and completely.
  • Stage 3: Ultrasound Examination
    To evaluate how well the medications on your ovaries are working, a vaginal ultrasound test is performed at regular intervals. If the outcome is bad, it's possible that your doctor will suggest stopping the IVF treatment cycle. You and your doctor will decide together on this.
  • Stage 4: Egg Retrieval
    The egg retrieval procedure is carried out 36 hours following your hormone IVF injections given for stimulation. Transvaginal sonography is used to help retrieve eggs from the ovaries while the patient is under general anesthesia. Your reaction to the medications will determine how many eggs are collected, and the operation lasts 15 to 30 minutes. Around two to three hours following the treatment, you can leave for home. Sometimes there may be some stomach pain and vaginal spotting, but these symptoms usually go away in a day or two.
  • Stage 5: Sperm Collection
    A sample of semen is required from your spouse. On the day the eggs are harvested, a sample of fresh semen is often taken. A previously frozen sample can also be used, though, if a fresh sample can't be made on the same day or if the spouse isn't there on the day, the eggs are collected. The sperm and the eggs will be combined by a technician in a petri dish. If it fails to result in embryos, your doctor can choose to perform ICSI.
  • Stage 6: Fertilizing the Eggs
    The eggs will be fertilized in the laboratory, either through ICSI or traditional IVF. The embryologist will check the eggs the following day to see whether they have been fertilized and then later to see if any embryos have developed further. It is possible to freeze additional well-developed embryos if there are more than three for eventual later transfer.
  • Stage 7: Embryo Culture
    The fertilized eggs (embryos) are nurtured in a controlled environment, allowing them to grow and develop.
  • Stage 8: Embryo Transfer
    This is done two, three, or five days following egg harvest. To decide if a day 3 or day 5 transfer is necessary, embryologists keep an eye on the development and viability of the embryos. The embryo is positioned in your uterus using a tiny catheter that is implanted. It takes between six and ten days for the implantation to take place if the operation is successful. A course of medicines to assist the luteal phase will be provided to you after the transfer.
  • Stage 9: Pregnancy Test
    A pregnancy blood test is carried out after two weeks following extraction. In the event that the test is positive, the patient is thought to be four weeks pregnant.

At Hzb Arogyam Fertility Care and Endoscopy Centre, our experts conduct Sperm DNA Fragmentation (DFI) testing through a simple and non-invasive procedure:

A person in a lab coat holds a glass containing a colorful liquid, standing in a laboratory setting.

Why Choose Arogyam IVF?

At Arogyam IVF, we offer a comprehensive range of fertility treatments, backed by a strong network, experienced doctors,

and a patient-centric approach. Here's what sets Arogyam IVF apart:​​​​

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  1. Exceptional Success Rates: Arogyam IVF has achieved remarkable success rates, thanks to our cutting-edge technology, expert doctors, and personalized care.

  2. State-of-the-Art Infrastructure: Our modern fertility clinic is equipped with the latest technology, ensuring efficient and effective treatment.

  3. Experienced Fertility Specialists: Our team of experienced fertility doctors works closely with each patient, providing expert guidance and tailored treatment plans.

  4. Personalized Fertility Treatment: We recognize that each couple's fertility journey is unique. Our personalized approach focuses on individual medical history, diagnosis, and specific needs.

  5. Comprehensive Fertility Services: Arogyam IVF offers a wide range of fertility treatments, including IVF, ICSI, IUI, Cryopreservation, and Donor Programs.

  6. Patient-Centric Care: Our dedicated team provides compassionate support and guidance throughout your fertility journey, ensuring a seamless and stress-free experience.​

Frequently Asked Question's

  • Stage 1: Birth Control Pills or Oestrogen
    Your doctor may recommend oestrogen or birth control tablets before you begin IVF therapy. This is used to regulate the time of your menstrual cycle and prevent the growth of ovarian cysts. It enables your doctor to manage your treatment and increase the number of mature eggs collected during the egg retrieval operation.
  • Stage 2: Ovarian Stimulation
    In a normal woman, each menstrual cycle results in the production of one egg. However, several eggs are necessary for IVF. The likelihood of creating a healthy embryo improves when more than one egg is used. To boost your body's egg production, you'll be given fertility medications. You'll be prescribed injectable hormone medications during your IVF cycle to encourage all of the eggs in that cycle to develop at once and completely.
  • Stage 3: Ultrasound Examination
    To evaluate how well the medications on your ovaries are working, a vaginal ultrasound test is performed at regular intervals. If the outcome is bad, it's possible that your doctor will suggest stopping the IVF treatment cycle. You and your doctor will decide together on this.
  • Stage 4: Egg Retrieval
    The egg retrieval procedure is carried out 36 hours following your hormone IVF injections given for stimulation. Transvaginal sonography is used to help retrieve eggs from the ovaries while the patient is under general anesthesia. Your reaction to the medications will determine how many eggs are collected, and the operation lasts 15 to 30 minutes. Around two to three hours following the treatment, you can leave for home. Sometimes there may be some stomach pain and vaginal spotting, but these symptoms usually go away in a day or two.
  • Stage 5: Sperm Collection
    A sample of semen is required from your spouse. On the day the eggs are harvested, a sample of fresh semen is often taken. A previously frozen sample can also be used, though, if a fresh sample can't be made on the same day or if the spouse isn't there on the day, the eggs are collected. The sperm and the eggs will be combined by a technician in a petri dish. If it fails to result in embryos, your doctor can choose to perform ICSI.
  • Stage 6: Fertilizing the Eggs
    The eggs will be fertilized in the laboratory, either through ICSI or traditional IVF. The embryologist will check the eggs the following day to see whether they have been fertilized and then later to see if any embryos have developed further. It is possible to freeze additional well-developed embryos if there are more than three for eventual later transfer.
  • Stage 7: Embryo Culture
    The fertilized eggs (embryos) are nurtured in a controlled environment, allowing them to grow and develop.
  • Stage 8: Embryo Transfer
    This is done two, three, or five days following egg harvest. To decide if a day 3 or day 5 transfer is necessary, embryologists keep an eye on the development and viability of the embryos. The embryo is positioned in your uterus using a tiny catheter that is implanted. It takes between six and ten days for the implantation to take place if the operation is successful. A course of medicines to assist the luteal phase will be provided to you after the transfer.
  • Stage 9: Pregnancy Test
    A pregnancy blood test is carried out after two weeks following extraction. In the event that the test is positive, the patient is thought to be four weeks pregnant.

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